Learning Outcomes By the end of this section, you should be able to: Bile acid sequestrants, fibrates, and niacin vary in their mechanism, therapeutic effect, and side effect profile. Table 21.6 lists common bile acid sequestrants, fibrates, and niacin and typical routes…
Learning Outcomes By the end of this section, you should be able to: Statin drugs are some of the most common drugs taken in the United States and are the mainstays of cholesterol-lowering pharmacologic therapy. Depending on the dose, they…
Learning Outcomes By the end of this section, you should be able to: Understanding Lipids Triglycerides are the main dietary source of fat. They are composed of three long fatty acid chains attached to a glycerol backbone, as depicted in Figure 21.2.…
Figure 21.1 The heart is the primary organ of the cardiovascular system, controlling circulation and blood flow for the entire body. (attribution: Copyright Rice University, OpenStax, under CC BY 4.0 license) Chapter Outline 21.1 Introduction to Lipoprotein and Apolipoproteins 21.2 Statins (HMG-CoA Reductase Inhibitors) and PCSK9…
This chapter described the physiology of forming a blood clot, including review of the coagulation cascade and platelet activation. It examined the various medications for prevention and treatment of thromboembolism. Anticoagulant mediations were summarized, including both injectable and oral forms.…
Learning Outcomes By the end of this section, you should be able to: Thrombolytics to Break Down an Existing Clot Anticoagulant and antiplatelet medications work in the clotting cascade to prevent clotting in clients without a thromboembolism or to prevent…
Learning Outcomes By the end of this section, you should be able to: Antiplatelet drugs work by decreasing platelet activation and/or platelet adhesion. They are used for various indications including prevention and treatment of cardiovascular disease and prevention of ischemic…
Learning Outcomes By the end of this section, you should be able to: Anticoagulants Used as Blood Thinners Anticoagulants are commonly referred to as blood thinners. They work in different parts of the coagulation cascade to decrease the propensity of the blood…
Learning Outcomes By the end of this section, you should be able to: The ability of the blood to form clots in response to tissue damage is essential for hemostasis, or the body’s ability to stop bleeding. However, clot formation also…
Figure 20.1 The heart is the primary organ of the cardiovascular system, controlling circulation and blood flow for the entire body. (attribution: Copyright Rice University, OpenStax, under CC BY 4.0 license) Chapter Outline 20.1 Introduction to Clotting and Coagulation 20.2 Anticoagulants 20.3 Antiplatelets 20.4 Thrombolytics Blood…