There are three main recognized types of mesothelioma:

- Pleural mesothelioma: The most common form of the disease, accounting for roughly 70% of cases, and occurs in the lining of the lung known as the pleura.
- Peritoneal mesothelioma: It occurs in the lining of the abdominal cavity, known as the peritoneum.
- Pericardial mesothelioma: It originates in the pericardium, which lines the heart. It is the rarest of the major types of asbestos-related cancer.
- Testicular mesothelioma: Rare, found in the testicles.
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