What are the 3 basic concepts of pharmacology?
Pharmacokinetic parameters include drug absorption into the body, distribution of the drug throughout the body, and metabolism and elimination of the drug from the body.
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What are the 5 pillars of pharmacology?
It encompasses a series of essential stages, known as the five pillars of drug discovery. These pillars include target identification and validation, lead discovery, lead optimization, preclinical testing, and clinical trials.
Who is the father of pharmacology?
Jonathan Pereira (1804–1853), the Father of Pharmacology.
Chapter Summary
This chapter focused on cardiac emergency and shock drugs. Cardiac emergencies can arise from problems within the heart’s electrical system or mechanical system and include AMI, unstable angina, and dysrhythmias. Both conduction problems and mechanical problems can affect cardiac output…
Shock Drugs
Learning Outcomes By the end of this section, you should be able to: Shock is a state of medical emergency in which tissues are not receiving enough oxygenated blood to sustain life. If not treated rapidly, decreased perfusion will cause…
Cardiac Emergency Drugs
Learning Outcomes By the end of this section, you should be able to: The goal of treatment for a client with AMI or unstable angina is restoring the blood supply to the affected area of the heart muscle. Drugs can…
Introduction to Cardiac Emergencies and Shock
Learning Outcomes By the end of this section, you should be able to: Cardiac Emergencies The primary responsibility of the heart is to generate cardiac output. Cardiac output (CO) is a function of heart rate (HR) and stroke volume (SV): CO=HR × SV(SV): CO=HR × SV. Normal resting…
Introduction
Figure 22.1 The heart is the primary organ of the cardiovascular system, controlling circulation and blood flow for the entire body. (attribution: Copyright Rice University, OpenStax, under CC BY 4.0 license) Chapter Outline 22.1 Introduction to Cardiac Emergencies and Shock 22.2 Cardiac Emergency Drugs…
Chapter Summary
This chapter reviewed lipid-lowering drugs. It introduced lipoproteins, including their metabolism and their connection to CAD. Many classes of lipid-lowering medications were described, along with salient nursing implications and client education.
Cholesterol Absorption Inhibitors
Learning Outcomes By the end of this section, you should be able to: Ezetimibe is a cholesterol absorption inhibitor. It works by inhibiting the cholesterol transporter called Niemann-Pick C1-Like 1 (NPC1L1). It lowers LDL-cholesterol levels by 13%–20% (Grundy et al., 2019).…